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Rabbit Anti-HIPK1/Gold Conjugated antibody (bs-17403R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-17403R-Gold
英文名稱 Rabbit Anti-HIPK1/Gold Conjugated antibody
中文名稱 膠體金標記的核小體相關激酶HIPK1抗體
別    名 Hipk 1; Hipk1; HIPK1_HUMAN; Homeodomain interacting protein kinase 1; Homeodomain interacting protein kinase 1 like protein; Homeodomain-interacting protein kinase 1; Myak; Nbak 2; Nbak2; Nuclear body associated kinase 2; Nuclear body associated kinase 2b.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 細胞生物  信號轉(zhuǎn)導  激酶和磷酸酶  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Macaque Monkey)
產(chǎn)品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 131kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HIPK1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008]

Function:
May play a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. May be involved in malignant squamous cell tumor formation.

Subcellular Location:
Nucleus. Cytoplasm. Predominantly nuclear.

Tissue Specificity:
Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines.

Post-translational modifications:
Autophosphorylated. Phosphorylated and activated by JNK1.

Similarity:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 204851 Human

Entrez Gene: 15257 Mouse

Entrez Gene: 365895 Rat

Omim: 608003 Human

SwissProt: Q86Z02 Human

SwissProt: O88904 Mouse

SwissProt: A4L9P5 Rat

Unigene: 532363 Human

Unigene: 20827 Mouse

Unigene: 4151 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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