| 產(chǎn)品編號(hào) | bs-16716R |
| 英文名稱 | TRF41 Rabbit pAb |
| 中文名稱 | DNA聚合酶Κ抗體 |
| 別 名 | DNA polymerase kappa; DNA polymerase sigma; LAK 1; LAK-1; LAK1; OTTHUMP00000115520; PAP associated domain containing 7; PAP-associated domain-containing protein 7; Papd7; PAPD7_HUMAN; POLK; POLS; Polymerase(DNA directed) sigma; Polymerase DNA Directed Sigma; Terminal uridylyltransferase 5; Topoisomerase related function protein 4 1; Topoisomerase-related function protein 4-1; TRF4 1; TRF4; TRF4-1; TRF41; TUTase 5; TUTASE5. |
| 研究領(lǐng)域 | 細(xì)胞生物 表觀遺傳學(xué) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | Human (predicted: Mouse,Rabbit,Pig,Cow,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 60 kDa |
| 檢測(cè)分子量 | |
| 細(xì)胞定位 | 細(xì)胞核 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TRF41: 701-772/772 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene is a DNA polymerase that is likely involved in DNA repair. In addition, the encoded protein may be required for sister chromatid adhesion. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jan 2010] Function: DNA polymerase, probably involved in DNA repair. May play a role in sister chromatid cohesion. Does not play a role in replication-dependent histone mRNA degradation. Subunit: Component of a nuclear TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of an helicase (SKIV2L2/MTR4), an oligadenylate polymerase (PAPD5 or PAPD7), and a substrate specific RNA-binding factor (ZCCHC7 or ZCCHC8). Several TRAMP-like complexes exist with specific compositions and are associated with nuclear, or nucleolar RNA exosomes. Subcellular Location: Cytoplasm {ECO:0000269|PubMed:23376078}. Nucleus, nucleoplasm {ECO:0000269|PubMed:23376078}. Note=Excluded from nucleolus, weak staining detected in the cytoplasm. Similarity: Belongs to the DNA polymerase type-B-like family. Contains 1 PAP-associated domain. SWISS: Q5XG87 Gene ID: 11044 Database links: Entrez Gene: 11044 Human Omim: 605198 Human SwissProt: Q5XG87 Human Unigene: 481542 Human |
| 產(chǎn)品圖片 |
Tissue/cell: human laryngo carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-TRF41 Polyclonal Antibody, Unconjugated(bs-16716R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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