| 產(chǎn)品編號 | bsm-62384R |
| 英文名稱 | MICA Recombinant Rabbit mAb |
| 中文名稱 | MHC I類鏈相關(guān)蛋白A/組織相容性復(fù)合物MHCIa重組兔單抗 |
| 別 名 | PERB11.1; MICA. |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號 | 18A14 |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | WB=1:500-1:2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 43 kDa |
| 檢測分子量 | 42-70 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human MIC A: 80-134 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. SWISS: Q29983 Gene ID: 4276 MICA蛋白是一種細(xì)胞應(yīng)激分子，在正常組織中表達(dá)量少，僅在腸道上皮組織表達(dá)量稍高，但是在多種腫瘤細(xì)胞，尤其是上皮源性的腫瘤如肺癌、乳腺癌、腎癌、卵巢癌、結(jié)腸癌等細(xì)胞表面高表達(dá)，并在細(xì)胞發(fā)生癌變的早期階段出現(xiàn)在細(xì)胞表面。 該分子與相應(yīng)受體NKG2D結(jié)合后可激活NK細(xì)胞、Vd1 gd T細(xì)胞、CD8+ T細(xì)胞的細(xì)胞毒作用，從而產(chǎn)生殺傷腫瘤細(xì)胞的生物效應(yīng)。因此，抗MICA特異性抗體在腫瘤早期診斷、治療中可能具有更高的敏感性和療效，從而可實現(xiàn)腫瘤的“早診斷、早治療”。并且還能對其它治療方案的療效進(jìn)行早期評估。 |
| 產(chǎn)品圖片 |
25 ug total protein per lane of various lysates (see on figure) probed with MICA monoclonal antibody, unconjugated (bsm-62384R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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