| 產(chǎn)品編號(hào) | bsm-62176R |
| 英文名稱 | Granulin Recombinant Rabbit mAb |
| 中文名稱 | 顆粒蛋白前體重組兔單抗 |
| 別 名 | Acrogranin; CLN11; GEP; GP88; Granulins; GRN; PCDGF; PEPI; PGRN; Proepithelin; Progranulin. |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | WB=1:1000-1:2000,IHC-P=1:100-1:200,IHC-F=1:100-1:200,IF=1:50-1:200,Flow-Cyt=1:20-1:100,ICC/IF=1:50-1:200,IP=1:20-1:50
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 64 kDa |
| 檢測(cè)分子量 | 55,75 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human Progranulin: 15-85/593 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. SWISS: P28799 Gene ID: 2896 1.PGRN目前主要用于老年癡呆疾病。是65歲以下人群中第二種最常見的 癡呆形式，該蛋白的多量產(chǎn)生，能夠損壞記憶和個(gè)性，而且還可能影響運(yùn)動(dòng)。這一發(fā)現(xiàn)也許可幫助解決關(guān)于該疾病病因的困惑： 癡呆癥(FTD)是常見的神經(jīng)退化疾病，可見，除微管相關(guān)的tau蛋白導(dǎo)致癡呆癥外，又一個(gè)新的與癡呆癥有關(guān)蛋白又被科學(xué)家發(fā)現(xiàn)。 2.顆粒蛋白前體（PGRN）在調(diào)節(jié)生長(zhǎng)發(fā)育、損傷修復(fù)和促進(jìn)細(xì)胞增殖等方面發(fā)揮重要作用。PGRN能促進(jìn)腫瘤細(xì)胞過度增殖、增強(qiáng)細(xì)胞向外周侵襲的能力以及促進(jìn)腫瘤組織血管新生，提示它可能是腫瘤治療的一個(gè)非常重 |
| 產(chǎn)品圖片 |
Western blot analysis of 293T cell lysate. Using Granulin (bsm-62176R) monoclonal antibody at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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