| 產(chǎn)品編號 | bsm-61961R |
| 英文名稱 | SFRP4 Recombinant Rabbit mAb |
| 中文名稱 | 子宮內(nèi)膜重組兔單抗 |
| 別 名 | FRP4; FrpHE; PYL; Sfrp4. |
| 抗體來源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號 | 6D4 |
| 交叉反應(yīng) | Human,Mouse,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:500-1:2000,IHC-P=1:100-1:200,IHC-F=1:100-1:200,IF=1:50-1:200,Flow-Cyt=1:20-1:100,ICC/IF=1:50-1:200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 40 kDa |
| 檢測分子量 | 50 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human SFRP 4: 251-300/346 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SWISS: Q6FHJ7 Gene ID: 6424 抗子宮內(nèi)膜抗體屬于自身抗體，在正常育齡婦女中也可以檢測到，但在不孕癥人群中，特別是患有子宮內(nèi)膜異位癥的婦女中更多見。 正常機體具有自身免疫調(diào)節(jié)功能，產(chǎn)生極弱的自身抗體，幫助清除體內(nèi)衰老變性的自身成分，但由于某種原因?qū)е旅庖呦到y(tǒng)對自身組織產(chǎn)生過度免疫應(yīng)答，則會發(fā)生過強的一系列免疫反應(yīng)，致使所侵及的組織免疫活性細(xì)胞增多，免疫復(fù)合物沉積，而導(dǎo)致功能改變。當(dāng)這種抗子宮內(nèi)膜抗體由于反復(fù)刺激而大量產(chǎn)生達(dá)到一定的含量時，可與自身的子宮內(nèi)膜組織發(fā)生抗原抗體結(jié)合反應(yīng)，并激活免疫系統(tǒng)引起損傷性效應(yīng)，造成子宮內(nèi)膜組織細(xì)胞生化代 |
| 產(chǎn)品圖片 |
25 ug total protein per lane of various lysates (see on figure) probed with SFRP4 monoclonal antibody, unconjugated (bsm-61961R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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